cGMP-induced differentiation of the promyelocytic cell line HL-60.
نویسندگان
چکیده
منابع مشابه
Eosinophilic differentiation of the human promyelocytic leukemia cell line, HL-60
HL-60 promyelocytic leukemia cells differentiated to eosinophils and eosinophilic precursors when cultured under mildly alkaline conditions (pH 7.6-7.8) for 7 d without refeeding. New cytoplasmic granules appeared blue in the least mature cells and red in the most mature cells when stained with Wright-Giemsa. The granules also stained with Luxol-fast-blue, a characteristic of eosinophil granule...
متن کاملDNA repair in human promyelocytic cell line, HL-60.
The human promyelocytic cell line, HL-60, shows large changes in endogenous poly(ADP-ribose) and in nuclear ADP-ribosyl transferase activity (ADPRT) during its induced myelocytic differentiation. DNA strand-breaks are an essential activator for this enzyme; and transient DNA strand breaks occur during the myelocytic differentiation of HL-60 cells. We have tested the hypothesis that these post-m...
متن کاملThe HL - 60 Promyelocytic Leukemia Cell Line : Proliferation , Differentiation , and Cellular Oncogene Expression By Steven
A LTHOUGH LEUKEMIC cells from patients with acute myeloid leukemia display a seemingly unlimited proliferative capacity in vivo, their life span in liquid suspension culture is usually limited to a few cell divisions. One possible explanation for such limited in vitro proliferation is that certain growth factors sustaining leukemic cell division in the patient are absent from the in vitro cultu...
متن کاملThe HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.
The HL-60 cell line, derived from a single patient with acute promyelocytic leukemia, provides a unique in vitro model system for studying the cellular and molecular events involved in the proliferation and differentiation of normal and leukemic cells of the granulocyte/monocyte/macrophage lineage.
متن کاملProtein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60.
Protein kinase C (PKC) from human promyelocytic leukemia HL-60 cells can be resolved into three fractions (peak, a, b and c) by hydroxyapatite column chromatography. Peak a and c enzymes are indistinguishable from the brain type II PKC having beta (beta I and beta II)-sequence and type III having alpha-sequence, respectively. Peak b enzyme is a previously unidentified PKC subspecies that has en...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1989
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.86.18.7174